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GAN applications in disease subtypes discovery (four-dimensional coordinate system developed by SMILE-GAN). (A) Voxel-wise statistical comparison (onesided t-test) between cognitive normal subjects and subjects that predominantly belong to each of the four Alzheimer’s disease neuroanatomical patterns. (B) Visualization of subjects that belong to the four subtype clusters in a diamond plot. Images are taken and adapted from Yang et al. (2021).
