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. Author manuscript; available in PMC: 2024 Mar 2.
Published in final edited form as: Mol Cell. 2023 Jan 23;83(5):731–745.e4. doi: 10.1016/j.molcel.2022.12.033

Figure 3. SPOP cancer mutations line novel interfaces in the SPOP cryo-EM structure.

Figure 3.

Previously unexplainable mutations are found in the MATH:MATH and β-extension interfaces, and in the glue pad. A ridge of highly clustered mutations follows the face of the MATH domain that is positioned towards the interior of the filament (black callout box). This mutation ridge contains the cluster of charge-altering mutations that span the MATH:MATH interface (black and yellow). An additional cluster of cancer mutations is found in the glue pad (blue callout box), including the endometrial cancer mutation W22R and Y327C/Y327F in hepatocellular carcinoma and lung adenocarcinoma, respectively.