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. 2023 Mar 7;14:1219. doi: 10.1038/s41467-023-36820-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — LOH induced by long gene conversion tracts. Schematic map of 27 informative genome variants or SNPs located upstream and downstream at various distances from the homozygous MYBPC3 locus differentiating parental alleles in MYBP3^homo-Indel and MYBPC3^homo-WT ESC clones derived from edited embryos. LOH at each SNP site and genome variant was determined and compared to ESC clones with MYBPC3^Indel/Indel genotype from same egg and sperm donors. LOH and direction of conversion tract in each clone is indicated in color lines. Red lines indicate that these loci lost paternal nucleotides and become homozygous maternal. Green lines indicate that these loci are homozygous but LOH cannot be determined because of initial heterozygosity in contributing gametes. Black lines indicate that these loci are heterozygous. Source Data are provided as Supplementary Data 9.