FIGURE 2.

Representative images showing pathological effects in the absence and presence of meldonium on brain and lung tissue injury under acute high-altitude hypoxia. (A) Representative figures of lung tissue using HE staining (200×). (B) Quantitative and representative doppler blood flow map (n = 6, mean ± SEM). ^### p < 0.001 compared to the normoxia group; ^* p < 0.05 compared to the high-altitude hypoxia with saline group. The data were analyzed using one-way ANOVA analysis of variance with Tukey’s post-tests. H-25, H-50, H-100, H-200, H-400, indicate different doses of meldonium under hypoxia, respectively, and H-ACZ indicates the administration of acetazolamide under hypoxia.