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. 2023 Feb 22;14:1119046. doi: 10.3389/fphar.2023.1119046

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Copyright © 2023 Liu, Sui, Wang, Li, Yang, Yang, Xiao, Sun, Guo, Yang, Yang, Wang and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Detection of parameters related to meldonium pharmacokinetics. (A) Drug concentration-time curves of meldonium content in serum after i.,g. administration between normoxia groups (25 and 50 mg/kg) and high-altitude groups (25, 50, and 100 mg/kg, n = 6); (B) Comparison of drug concentration time profiles of meldonium (50 mg/kg) after i.g., administration in high-altitude and normoxia groups (n = 3); (C) Drug concentration-time curves of meldonium (25 mg/kg) after i.v., and i.g., administration between high-altitude and normoxia groups (n = 3); (D) The 3-hydroxypropionic acid and succinic acid content of meldonium after incubation in liver homogenates (n = 3). The data were analyzed using one-way ANOVA analysis of variance with Tukey’s post-tests.