TABLE 2.
Pharmacokinetic parameters of meldonium in rat blood plasma between normoxia and hypoxia.
| PK parameters | Normoxia | Normoxia | Hypoxia | Hypoxia | Hypoxia |
|---|---|---|---|---|---|
| 25 mg/kg meldonium | 50 mg/kg meldonium | 25 mg/kg meldonium | 50 mg/kg meldonium | 100 mg/kg meldonium | |
| Tmax (h) | 3.00 ± 1.73 | 3.04 ± 1.58 | 4.33 ± 3.14 | 1.83 ± 1.17 | 1.33 ± 0.52 |
| Cmax (ng/mL) | 2,709.92 ± 649.7 | 24,904.97 ± 22,618.59 | 7,321.69 ± 2060.91 a | 11,118.71 ± 3,515.13 a | 25,761.42 ± 8,678.83 |
| AUCall (h*ng/mL) | 17,415.21 ± 3,925.96 | 171,805.85 ± 36,723.18 | 86,443.85 ± 39,554.66 a | 162,116.00 ± 39,767.98 | 329,712.29 ± 115,319.66 |
| Vz/F (mL/kg) | 5,335.80 ± 1,286.73 | 2,773.03 ± 756.42 | 3,302.48 ± 1,139.24 | 5,032.12 ± 1,679.62 a | 4,773.61 ± 1,194.83 |
| CL/F (mL/h/kg) | 1,400.32 ± 362.55 | 251.50 ± 56.98 | 230.76 ± 149.96 a | 182.54 ± 76.49 | 170.40 ± 72.21 |
| MRTlast (h) | 4.34 ± 0.58 | 7.43 ± 1.25 | 8.40 ± 1.36 a | 10.20 ± 1.29 | 9.09 ± 1.79 |
a
Note: p < 0.05 compared to the normoxia group.
Tmax, time taken to attain maximum concentration.
Cmax, Maximum concentration achieved in the blood.
AUCall, area under concentration-time curve for the period from 0 min to infinity time.
Vz/F, the apparent volume of distribution.
CL/F, clearance rate.
MRTlast, last mean residence time.