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. 2022 Nov 13;32(4):497–506. doi: 10.1007/s10068-022-01199-5

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© The Korean Society of Food Science and Technology 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 1 — Cytotoxicity of Lactococcus lactis subsp. lactis LM1185 on RAW 264.7 cells and Effect of Lactococcus lactis subsp. lactis LM1185 on NO production in the RAW 264.7 cells. A Cytotoxicity of Lactococcus lactis subsp. lactis LM1185 on RAW 264.7 cells. Raw 264.7 cells (5 × 10⁴ cells/well) were treated with different cell number of L. lactis subsp. lactis LM1185. The results showed that all MOI of L. lactis subsp. lactis LM1185 had no cytotoxicity on RAW 264.7 cells. Data are presented as mean ± SD of three independent experiments. Noted asterisks indicate statistical significance (*P < 0.05, **P < 0.01). B Effect of Lactococcus lactis subsp. lactis LM1185 on NO production in the RAW 264.7 cells. RAW 264.7 cells were cultured with 5 × 10⁵ cells/well. RAW 264.7 cells treated with 1 μg/mL of LPS or L. lactis subsp. lactis LM1185. When RAW 264.7 cells treated with 5 × 10⁷ cells of L. lactis subsp. lactis LM1185, the highest NO production was detected. Asterisks indicate statistical significance (*P < 0.05, *** P < 0.001)