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. 2023 Mar 7;14:1267. doi: 10.1038/s41467-023-36735-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Super-enhancer calling (present in at least 2 samples and not overlapping with H3K4me3 5 kb from transcription start site) downstream of the SOX11 locus in NB tumors (MNA = adrenergic MYCN amplified, MES = mesenchymal, MNoA-LR = adrenergic MYCN non-amplified low-risk, MNoA-HR = adrenergic MYCN non-amplified high-risk) and NB cell lines (MNA = adrenergic MYCN amplified, MES = mesenchymal, MNoA = adrenergic MYCN non-amplified) (GSE136209)¹⁴. b Violin plot showing super-enhancer signal for each individual NB cell line colored by their ChIP-seq signature defined subgroup (GSE136209)¹⁴. c Violin plot showing super-enhancer signal for each individual NB tumors colored by their ChIP-seq signature defined subgroup (GSE136209)¹⁴. d (Left) Correlation of SOX11 expression with super-enhancer signal of the consensus super-enhancer in a dataset of 25 NB cell lines, colored by their ChIP-seq signature defined subgroup (p-value = 8.39e-5, R-value = 0.774, two-tailed Spearman correlation). (Right) Correlation of SOX11 expression with super-enhancer signal of the consensus super-enhancer in a dataset of 47 NB tumors, colored by their ChIP-seq signature defined subgroup (p-value = 1.25e-10, R-value = 0.778, two-tailed Pearson correlation) (GSE136209)¹⁴. Trend line is shown with 95% confidence interval. For Fig. 2b–d, source data are provided as Source Data file.