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NICD activation of LEF-1 is independent of β-catenin. NICD augments activity of Δ56LEF. Neuro-2A cells were transfected with 7xLEF-luc and expression plasmids for Δ56LEF (LEF-1 lacking the β-catenin interaction domain) and β-catenin as indicated (left panel, black bars). Cells were also transfected with LEF-OT and expression plasmids for Δ56LEF and NICD as indicated (right panel, gray bars). Results are given as fold induction relative to the reporters alone.
