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. 2023 Mar 7;13:3485. doi: 10.1038/s41598-022-17213-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Using MFCSC to detect bilateral pairs where FC asymmetry is indicative of the direction and extent of functional hemispheric dominance. (A) Pairs that had leftward FC asymmetry, i.e. FC_[L] > FC_[R] (p < 0.00006; Bonferroni corrected with alpha set to 0.05), with colour intensity indicating FC strength, and other conventions as in Fig. 3. (B) Excluding connections with mFCSC_[L] ≠ mFCSC_[R] (connections to exclude correspond to the top row of Fig. 3, which is reproduced within the rectangle). (C) The subset of the pairs in panel A where left and right unilateral connections probably share the same brain function (as mFCSC is not different between hemispheres). In these pairs, FC asymmetry is a good indicator for the direction and magnitude of functional hemispheric dominance. (D–F) Same conventions as (A–C), but for the analysis of pairs that had rightward FC asymmetry.