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. 2023 Feb 24;120(9):e2211823120. doi: 10.1073/pnas.2211823120

Table 1.

Comparison of homolog detection methods in the max50 dataset

Pfam Gene3D SUPERFAMILY
Method AUC AUC1000 AUC AUC1000 AUC AUC1000
PROST 99.0 97.2 98.9 95.7 98.5 95.5
CSBLAST 97.0 92.4 96.3 91.0 96.1 90.0
PHMMER 96.4 92.3 96.2 90.4 95.9 90.4
NCBI-BLAST 95.9 90.9 94.4 87.9 93.7 85.7
ESM1bL34M 96.0 89.8 91.9 80.1 92.0 81.1
FASTA 94.6 88.8 93.2 85.2 91.9 83.4