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. 2023 Feb 22;13:1040665. doi: 10.3389/fonc.2023.1040665

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Copyright © 2023 Pettersen, Øy, Egeland, Juell, Engebråten, Mælandsmo and Prasmickaite

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Growth of TNBC PDXs: paclitaxel sensitive MAS98.12 and the resistant sub-line MAS98.12PR with/without treatment. (A) Relative tumor volume (normalized to the volume at the day when the treatment was started) of the non-treated and the paclitaxel-treated (15 mg/kg, 2x/week for 3 weeks) MAS98.12. One of the treated tumors acquired resistance and re-grew, being the origin of the resistant sub-line MAS98.12PR; average ± SEM (n indicated in the legend). (B) Validation of the distinct sensitivity to paclitaxel (10 mg/kg, 2x/week) in the MAS98.12 and the daughter sub-line MAS98.12PR; average ± SEM (n indicated in the legend).