Table 2.
The results of Mendelian randomization analyses.
| Exposure | Used SNPs | inverse variance weighted method | Weighted median method | MR-Egger method | Cochrane's Q test | Pleiotropy | MR-PRESSO a | Outliers excluded b | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR(95% CI) | P-value | OR(95% CI) | P-value | OR(95% CI) | P-value | Q | P-value | MR-Egger intercept | se | P-value | Raw | Outliers | outlier-corrected | inverse variance weighted method | Weighted median method | MR-Egger method | Cochrane’s Q test | Pleiotropy | |||||||||||||
| casual estimate | sd | P-value | casual estimate | sd | P-value | OR(95% CI) | P-value | OR(95% CI) | P-value | OR(95% CI) | P-value | Q | P-value | MR-Egger intercept | se | P-value | |||||||||||||||
| ieu-b-73 | Alcoholic drinks per week | 33 | 0.903(0.599-1.359) | 0.624 | 0.651(0.409-1.036) | 0.070 | 0.884(0.341-2.292) | 0.802 | 65.832 | 0.000395 | 0.000386 | 0.00827 | 0.963 | -0.102 | 0.209 | 0.627 | rs28712821;rs28929474 | -0.219 | 0.169 | 0.206 | 0.804(0.577-1.120) | 0.196 | 0.633(0.402-0.996) | 0.0484 | 0.730(0.328-1.625) | 0.448 | 34.783 | 0.251 | 0.00170 | 0.00659 | 0.798 |
| ukb-b-5779 | Alcohol intake frequency | 92 | 1.173(0.999-1.378) | 0.0513 | 1.254(1.033-1.521) | 0.0221 | 1.192(0.722-1.967) | 0.494 | 174.852 | 3.05E-07 | -0.00039 | 0.00607 | 0.949 | 0.160 | 0.082 | 0.0544 | rs28768122;rs11940694 | 0.197 | 0.0763 | 0.0116 | 1.217(1.048-1.413) | 0.00993 | 1.270(1.0462-1.542) | 0.0157 | 1.624(1.010-2.610) | 0.0483 | 139.917 | 0.000464 | -0.00709 | 0.00566 | 0.213 |
| ukb-b-6324 | Processed meat intake | 23 | 1.315(0.797-2.168) | 0.284 | 1.284(0.746-2.208) | 0.367 | 1.020(0.079-13.254) | 0.988 | 39.941 | 0.0109 | 0.00384 | 0.0194 | 0.845 | 0.27300 | 0.255 | 0.295 | rs2029401 | 0.127 | 0.232 | 0.588 | 1.136(0.721-1.790) | 0.583 | 1.272(0.722-2.241) | 0.404 | 1.004(0.104-9.709) | 0.998 | 29.760 | 0.0969 | 0.00188 | 0.0172 | 0.914 |
| ukb-b-8006 | Poultry intake | 7 | 1.101(0.151-8.051) | 0.924 | 1.124(0.280-4.508) | 0.869 | 3.537E-18(4.064E-42-3.078E+06) | 0.212 | 32.126 | 1.54E-05 | 0.436 | 0.304 | 0.211 | 0.0963 | 1.015 | 0.928 | rs1051730;rs9997448 | 0.603 | 0.599 | 0.371 | 1.827(0.565-5.906) | 0.314 | 1.025(0.245-4.290) | 0.973 | 1.449E-14(6.521e-27-0.0322) | 0.116 | 5.256 | 0.262 | 0.354 | 0.158 | 0.111 |
| ukb-b-2862 | Beef intake | 14 | 0.807(0.307-2.124) | 0.664 | 0.462(0.198-1.080) | 0.0748 | 0.0556(0.000156-19.864) | 0.354 | 38.305 | 0.000257 | 0.0339 | 0.0375 | 0.383 | -0.215 | 0.494 | 0.671 | rs62169335;rs429358 | -0.318 | 0.387 | 0.428 | 0.479(0.227-1.012) | 0.0538 | 0.458(0.194-1.080) | 0.0745 | 0.0143(0.000152-1.351) | 0.0971 | 16.712 | 0.117 | 0.0449 | 0.0293 | 0.157 |
| ukb-b-17627 | Non-oily fish intake | 11 | 0.957(0.302-3.029) | 0.940 | 0.681(0.243-1.912) | 0.466 | 0.0187(0.000107-3.267) | 0.165 | 31.48 | 0.000488 | 0.0488 | 0.0320 | 0.161 | -0.0440 | 0.588 | 0.942 | rs56094641 | -0.433 | 0.554 | 0.455 | 0.648(0.219-1.923) | 0.435 | 0.430(0.144-1.285) | 0.131 | 0.0112(0.000155-0.810) | 0.0737 | 22.006 | 0.00886 | 0.0503 | 0.0264 | 0.093 |
| ukb-b-2209 | Oily fish intake | 60 | 0.739(0.501-1.091) | 0.128 | 0.713(0.479-1.062) | 0.0961 | 0.539(0.103-2.816) | 0.467 | 161.092 | 2.06E-11 | 0.00469 | 0.0122 | 0.702 | -0.302 | 0.199 | 0.134 | rs1421085;rs2952140 | -0.287 | 0.166 | 0.0885 | 0.751(0.543-1.038) | 0.0831 | 0.654(0.438- 0.977) | 0.0379 | 0.219(0.0570-0.842) | 0.0311 | 102.784 | 0.000193 | 0.0183 | 0.00991 | 0.0702 |
| ukb-b-5640 | Pork intake | 13 | 1.287(0.429-3.863) | 0.653 | 0.766(0.258-2.275) | 0.631 | 0.297(0.000244-361.855) | 0.744 | 30.325 | 0.00249 | 0.0152 | 0.0371 | 0.690 | 0.252 | 0.561 | 0.661 | rs12721051;rs2387807 | 0.203 | 0.459 | 0.668 | 1.225(0.498-3.013) | 0.658 | 0.755(0.247-2.308) | 0.622 | 1.173(0.000271-5073.120) | 0.971 | 13.455 | 0.199 | 0.000427 | 0.0416 | 0.992 |
| ukb-b-14179 | Lamb/mutton intake | 30 | 1.127(0.564-2.251) | 0.735 | 0.954(0.427-2.132) | 0.908 | 2.627(0.138-49.982) | 0.526 | 65.171 | 0.000135 | -0.00940 | 0.0162 | 0.567 | 0.120 | 0.353 | 0.737 | rs429358 | -0.133 | 0.335 | 0.694 | 0.875(0.454-1.687) | 0.691 | 0.843(0.405-1.755) | 0.648 | 0.303(0.0134-6.819) | 0.458 | 52.012 | 0.00382 | 0.0114 | 0.0167 | 0.499 |
| ukb-b-11348 | Bread intake | 25 | 0.942(0.615-1.442) | 0.784 | 0.884(0.520-1.501) | 0.647 | 1.090(0.146-8.164) | 0.934 | 34.310 | 0.0793 | -0.00212 | 0.0146 | 0.885 | -0.0596 | 0.217 | 0.786 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| ukb-b-1489 | Cheese intake | 61 | 0.876(0.678-1.132) | 0.310 | 1.019(0.727-1.427) | 0.914 | 0.513(0.172-1.533) | 0.237 | 89.582 | 0.00795 | 0.00919 | 0.00934 | 0.329 | -0.133 | 0.131 | 0.314 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| ukb-b-8089 | Cooked vegetable intake | 17 | 1.230(0.558-2.710) | 0.607 | 0.987(0.403-2.416) | 0.977 | 4.737(0.000627-35769.624) | 0.738 | 29.263 | 0.0222 | -0.0139 | 0.0469 | 0.770 | 0.207 | 0.403 | 0.614 | rs1421085 | -0.0178 | 0.371 | 0.962 | 0.982(0.475-2.031) | 0.962 | 0.648(0.253-1.654) | 0.364 | 3.737(0.00134-10436.562) | 0.750 | 21.594 | 0.119 | -0.0138 | 0.0416 | 0.745 |
| ukb-b-6066 | Tea intake | 39 | 0.827(0.621-1.101) | 0.192 | 0.897(0.641-1.255) | 0.526 | 0.963(0.512-1.809) | 0.907 | 63.357 | 0.00606 | -0.00326 | 0.00614 | 0.598 | -0.190 | 0.146 | 0.200 | rs2279844 | -0.232 | 0.136 | 0.0949 | 0.793(0.608-1.034) | 0.0865 | 0.847(0.601-1.194) | 0.344 | 1.053(0.590-1.877) | 0.863 | 52.559 | 0.0466 | -0.00615 | 0.00569 | 0.287 |
| ukb-b-3881 | Fresh fruit intake | 52 | 0.489(0.320-0.748) | 0.000954 | 0.462(0.255-0.838) | 0.0110 | 0.971(0.229-4.122) | 0.968 | 61.804 | 0.143 | -0.00659 | 0.00678 | 0.336 | -0.7150 | 0.217 | 0.00175 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| ukb-b-15926 | Cereal intake | 38 | 0.617(0.404-0.943) | 0.0256 | 0.607(0.373-0.987) | 0.0442 | 0.338(0.0546-2.095) | 0.252 | 72.903 | 0.000389 | 0.00882 | 0.0133 | 0.510 | -0.483 | 0.216 | 0.0317 | rs11940694 | -0.398 | 0.204 | 0.0586 | 0.671(0.450-1.001) | 0.0508 | 0.612(0.367-1.021) | 0.0601 | 0.291(0.0537-1.575) | 0.161 | 61.489 | 0.00511 | 0.0123 | 0.0123 | 0.325 |
| ukb-b-1996 | Salad / raw vegetable intake | 18 | 0.810(0.287-2.284) | 0.691 | 2.264(0.767-6.683) | 0.139 | 16.837(0.155-1824.858) | 0.254 | 41.510 | 0.000789 | -0.0329 | 0.0253 | 0.212 | -0.211 | 0.529 | 0.695 | rs10819082 | 0.0260 | 0.486 | 0.958 | 1.026(0.396-2.660) | 0.957 | 2.276(0.791-6.552) | 0.127 | 9.368(0.125-703.379) | 0.326 | 31.464 | 0.0117 | -0.0242 | 0.0235 | 0.320 |
| ukb-b-5237 | Coffee intake | 38 | 0.947(0.676-1.328) | 0.754 | 0.977(0.642-1.486) | 0.914 | 1.021(0.514-2.031) | 0.952 | 58.495 | 0.0137 | -0.00142 | 0.00575 | 0.807 | -0.0540 | 0.172 | 0.756 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| ukb-b-16576 | Dried fruit intake | 39 | 0.521(0.339-0.780) | 0.00287 | 0.478(0.290-0.788) | 0.00382 | 0.174(0.0263-1.153) | 0.0780 | 64.068 | 0.00514 | 0.0137 | 0.0117 | 0.251 | -0.652 | 0.219 | 0.00498 | rs11152349 | -0.729 | 0.202 | 0.000915 | 0.482(0.325-0.717) | 0.000312 | 0.477(0.284-0.801) | 0.00510 | 0.231(0.0398-1.343) | 0.112 | 52.398 | 0.0481 | 0.00923 | 0.0110 | 0.406 |
OR, Odds ratio; SNPs, Single-nucleotide polymorphisms; CI, Confidence interval; NA, Not available;
a: The results of MR-PRESSO are presented in the form of beta values, and there is a conversion relationship between beta values and OR, specifically beta=log(OR).
b:We repeated the Mendelian randomization analysis after removing outliers.