Table 1.

Summary of the radiochemistry data^a.

product	HPLC retention time (min)b	radio-HPLC retention time (min)b	RCY (%, In-111)	RCP (%, In-111)	RCY (%, Lu-177)	RCP (%, Lu-177)
HTK01169	14.14	15.30	93	88	99	99
7	13.94	14.76	90.9 ± 1.8	80.3 ± 2.2	98.9 ± 0.6	99.3 ± 0.3
8	14.43	14.93	83.2 ± 1.0	57.5 ± 0.1	97.1 ± 1.5	70.2 ± 2.6

^aFor all labellings, a molar activity of 20 MBq nmol⁻¹ was used. The RCY and RCP of [¹¹¹In]-7 are calculated based on n = 3, and of [¹⁷⁷Lu]-7, n = 3. The RCY and RCP of [¹¹¹In]-8 are calculated based on n = 2, and of [¹⁷⁷Lu]-8, n = 3. Labelling of HTK-1169 was only performed once with each radiometal as a proof-of-concept.

^bThe HPLC retention times are based on injections in the analytical column (Method 1). For the radio-HPLC, in particular, the retention times shown are for the In-111 labelled compounds.