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. 2023 Jan 17;38(2):226–237. doi: 10.3904/kjim.2022.292

Figure 1.

Figure 1

Upregulation of physiological pathways in artery-aorta with high expression of type 2 iodothyronine deiodinase (DIO2) in the Genotype-Tissue Expression database. (A) DIO2 expression levels in 432 human artery-aorta samples in the University of California Santa Cruz (UCSC) database. (B) Volcano plot of differentially expressed gene (DEG) between DIO2 top 25% group and DIO2 bottom 25% group. (C) Numbers of DEGs in a comparison of the samples in the highest quartile for DIO2 expression and those in the lowest quartile. (D) Upregulated biological processes in the Gene Ontology (GO) annotation associated with increased DIO2 expression. (E) Down-regulated biological processes in the GO annotation associated with increased DIO2 expression. TPM, transcripts per million; GO-BP, GO-Biological Process; MAPK, mitogen-activated protein kinase; cAMP, cyclic adenosine monophosphate; ER, endoplasmic reticulum; ATP, adenosine triphosphate; NADH, nicotinamide adenine dinucleotide hydrogen; CoA, coenzyme A.