Table 4.
Top 20 differentially regulated P. aeruginosa genes in dual-species biofilms treated with 5 µg ml−1 meropenem vs untreated dual-species biofilms
|
Gene ID |
log2 fold change |
P-value |
Padj |
|
|---|---|---|---|---|
|
Upregulated |
ampC |
5.515387278 |
7.06E-51 |
1.95E-47 |
|
PA4280.5 |
3.700797106 |
7.82E-06 |
0.0002259666295 |
|
|
PA0668.1 |
3.67825942 |
8.05E-06 |
0.0002315796869 |
|
|
PA4690.5 |
3.49778215 |
2.92E-05 |
0.0007129969543 |
|
|
PA5369.5 |
3.485074044 |
3.01E-05 |
0.0007281076683 |
|
|
PA4111 |
2.963866877 |
8.30E-18 |
1.99E-15 |
|
|
PA4690.2 |
2.605990986 |
0.003138749477 |
0.03261549984 |
|
|
PA5369.2 |
2.604799667 |
0.003142239391 |
0.03261549984 |
|
|
PA4280.2 |
2.596702641 |
0.003658501903 |
0.03633497754 |
|
|
PA0668.4 |
2.58797494 |
0.003177734857 |
0.03286039678 |
|
|
hcp1 |
2.353244054 |
1.14E-22 |
9.02E-20 |
|
|
PA0466 |
1.908730924 |
1.39E-11 |
1.30E-09 |
|
|
pchG |
1.899939854 |
1.07E-08 |
6.09E-07 |
|
|
PA0126 |
1.883859984 |
5.23E-13 |
6.57E-11 |
|
|
PA0050 |
1.820434031 |
2.26E-06 |
7.78E-05 |
|
|
clpV1 |
1.75537326 |
1.53E-11 |
1.37E-09 |
|
|
vgrG1 |
1.730154359 |
3.27E-12 |
3.37E-10 |
|
|
PA4222 |
1.708263864 |
2.26E-12 |
2.45E-10 |
|
|
PA0563 |
1.691305244 |
1.68E-11 |
1.47E-09 |
|
|
PA0086 |
1.677560955 |
4.89E-10 |
3.46E-08 |
|
|
Downregulated |
PA0627 |
−2.524464134 |
1.52E-15 |
2.79E-13 |
|
gfnR |
−2.418533396 |
8.72E-23 |
8.02E-20 |
|
|
PA0641 |
−2.404904976 |
2.04E-20 |
7.49E-18 |
|
|
PA0638 |
−2.364308134 |
4.30E-21 |
1.98E-18 |
|
|
PA0628 |
−2.298437047 |
1.97E-20 |
7.49E-18 |
|
|
PA0635 |
−2.263949045 |
1.95E-16 |
3.84E-14 |
|
|
PA0629 |
−2.260720569 |
5.93E-19 |
1.92E-16 |
|
|
PA0639 |
−2.220599378 |
2.18E-21 |
1.21E-18 |
|
|
PA0636 |
−2.211742782 |
4.17E-18 |
1.15E-15 |
|
|
PA0625 |
−2.099597686 |
3.91E-17 |
8.30E-15 |
|
|
PA0616 |
−2.045775386 |
2.09E-15 |
3.72E-13 |
|
|
PA3638 |
−2.041401724 |
2.33E-18 |
7.14E-16 |
|
|
PA0634 |
−1.982462548 |
1.30E-17 |
3.00E-15 |
|
|
PA1168 |
−1.971155931 |
1.76E-14 |
2.56E-12 |
|
|
PA0631 |
−1.92975403 |
4.75E-15 |
7.95E-13 |
|
|
PA0619 |
−1.919212071 |
1.02E-13 |
1.31E-11 |
|
|
PA3631 |
−1.891142906 |
4.13E-19 |
1.43E-16 |
|
|
PA0626 |
−1.882097335 |
5.95E-17 |
1.22E-14 |
|
|
PA0630 |
−1.820934828 |
4.77E-11 |
3.71E-09 |
|
|
PA0637 |
−1.809932956 |
1.14E-14 |
1.75E-12 |