Table 5.
Risk of laterality defect by genotype compared to reference CCDC39/CCDC40 group
| Genotype | Laterality | OR | 95% CI |
|---|---|---|---|
| DNAH5 | SIT + SA | 2.33 | 1.32–4.08 |
| SIT | 1.77 | 1.01–3.12 | |
| SA | 1.84 | 0.74–4.58 | |
| DNAI1 | SIT + SA | 1.18 | 0.47–3.01 |
| SIT | 1.64 | 0.64–4.25 | |
| SA | 0.32 | 0.04–2.83 | |
| CCDC103 | SIT + SA | 3.61 | 0.99–13.08 |
| SIT | 2.42 | 0.73–8.0 | |
| SA | 2.03 | 0.42–9.89 | |
| DNAH11 | SIT + SA | 1.58 | 0.74–3.37 |
| SIT | 1.64 | 0.77–3.53 | |
| SA | 0.94 | 0.25–3.50 | |
| SPAG1 | SIT + SA | 2.10 | 0.71–6.22 |
| SIT | 1.45 | 0.51–4.16 | |
| SA | 2.28 | 0.52–9.94 |
Definition of abbreviations: CCDC39 = coiled-coil domain containing 39; CCDC40 = coiled-coil domain containing 40; CCDC103 = coiled-coil domain containing 103; CI = confidence interval; DNAH5 = dynein axonemal heavy chain 5; DNAI1 = dynein axonemal intermediate chain 1; DNAH11 = dynein axonemal heavy chain 11; OR = odds ratio; SA = situs ambiguus; SIT = situs inversus totalis; SPAG1 = sperm associated antigen 1.