Table 7.
Risk of laterality defect within each genotype in those with two loss-of-function mutations compared to those with one or more not–loss-of-function mutations
| Genotype | Laterality | OR | 95% CI |
|---|---|---|---|
| DNAH5 | SIT + SA | 1.23 | 0.63–2.41 |
| SIT | 1.68 | 0.88–3.20 | |
| SA | 0.55 | 0.23–1.32 | |
| CCDC39/CCDC40 | SIT + SA | 1.07 | 0.30–3.84 |
| SIT | 1.11 | 0.30–4.16 | |
| SA | 0.91 | 0.10–8.36 | |
| DNAH11 | SIT + SA | 1.93 | 0.57–6.52 |
| SIT | 1.95 | 0.58–6.58 | |
| SA | 0.95 | 0.12–7.44 |
Definition of abbreviations: CCDC39 = coiled-coil domain containing 39; CCDC40 = coiled-coil domain containing 40; DNAH5 = dynein axonemal heavy chain 5; DNAH11 = dynein axonemal heavy chain 11; CI = confidence interval; OR = odds ratio; SA = situs ambiguus; SIT = situs inversus totalis.