Table 4.
Genotypic, Allelic and Carriage Rate Frequencies of Tp53 CDH1Genes Polymorphism in Controls (n=88) and Familial Breast Cancer Cases (n=88)
| Gene | Genotype /Allele |
Case N (%) | Control N (%) | OR ( 95%CI ) | P-Value | Adjusted OR ( 95%CI ) |
P-Value |
| TP53Variant | G>C/C | 34(19.3%) | 29(16.5%) | 0.647 (0.308–1.361) | 0.251 | 0.81 (0.1–6.89) | 0.851 |
| G>G/C | 32(18.2%) | 30(17.0%) | |||||
| Mutation not reported |
22(12.5%) | 29(16.5%) | Reference | Reference | -- | ||
| CDH1.Variant | C>C/T | 28(15.9%) | 14(8.0%) | 0.250 (0.082–0.759) | 0.014 | 1.07 (0.05–22.59) | 0.000 |
| C>T/T | 63(34.1%) | 40(29.1%) | |||||
| Mutation not reported |
07(4.0%) | 14(8.0%) | Reference | Reference | -- | ||
| ATM | A>G/C | 55(31%) | 52(29%) | 0.560 (0.212–1.512) | 0.256 | 1.07 (0.05–1.059) | 0.975 |
| A>G/G | 53(30%) | 58(35%) | |||||
| Mutation not reported |
0(0.0) | 0(0.0) | Reference | 0 | -- | -- |