Figure 4.

KEGG human metabolic map showing the clustering of related pathways associated with As exposure around four central themes. Each colored dot represents a metabolite associated with a specific As species. We identified four general metabolic paths, shown in rectangles and group labels. The lipid metabolism pathway was well represented by all As species. As^V was associated with xenobiotic metabolism. DMA was associated with energy metabolism and TCA cycle as well as metabolites related to one carbon metabolism such as vitamin B₆ and folate.