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. Author manuscript; available in PMC: 2023 Mar 8.
Published in final edited form as: Cell Rep. 2022 Dec 30;42(1):111915. doi: 10.1016/j.celrep.2022.111915

Figure 3. Somatodendritic dopamine release in response to stimulus trains.

Figure 3.

(A–D) Example traces (A) and quantification of amplitude (B) and charge (C, area under the curve) of D2-IPSCs evoked with a train of five electrical stimuli at 40 Hz, and ratio of the 5- to 1-stimulus D2-IPSC (D, single-stimulus amplitudes are from Figure 1C and were recorded in the same cells). Syt-1 control 20 cells/6 mice, and Syt-1 cKODA 23 cells/6 mice.

(E–H) Example traces of D2-IPSCs evoked by 5 stimuli at 1 Hz followed by a 5-stimulus train at 100 Hz (E), and quantification of the summed 5-stimulus D2-IPSC charge at 1 Hz (F), and the 5-stimulus amplitude (G) and charge (H) at 100 Hz. Syt-1 control 8 cells/3 mice, and Syt-1 cKODA 6 cells/2 mice.

Data are mean ± SEM; *p < 0.05, ***p < 0.005 as determined by Mann Whitney rank-sum tests (B–D) or unpaired Student’s t tests (F–H).