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. 2023 Mar 8;21:51. doi: 10.1186/s12915-023-01551-z

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Gene family related to symbiosis establishment and maintenance in Conchocele bisecta. A Schematic representation of bacterial recognition and immune response in C. bisecta. Both expansion and contraction events of gene families involved in these processes are illustrated, and the boxes that followed each gene indicate if a gene family has expanded (red), contracted (blue), or neither (white) in C. bisecta (right), Archivesica marissinica (middle) and Gigantidas platifrons (left). B Heat maps of significantly evolved Pfam domains implicated in recognition and homeostasis in the three symbiotic (Sym) bivalves (Conbis: C. bisecta; Arcmar: A. marissinica; Gigpla: G. platifrons), compared with asymbiotic (non-sym) relatives (Lutrhy: Lutraria rhynchaena; Mizyes: Mizuhopecten yessoensis; Modphi: Modiolus philippinarum; Pinfuc: Pinctada fucata; Cragig: Crassostrea gigas). C Left, phylogenetic tree based on amino acids of apolipoprotein H. Predicted Pfam domains for each gene are shown. Right, heatmap showing the tissue-specific expression (Gi, gill; Ma, mantle; Fo, foot; Ad, adductor) of ApoH (row-wise Z-score of TPM counts)