Table 4.
Factors Correlated with wiCD by Univariable and Multivariable Linear Mixed Analysis
| Variables | Univariable Model | Multivariable Model | ||
|---|---|---|---|---|
|
| ||||
| coefficient, 95% CI | P value | coefficient, 95% CI | P value | |
|
| ||||
| Smoking history, yes | 0.04 (−1.18, 1.27) | 0.944 | ||
| Smoking intensity, per 10 pack-year higher | −1.09 (−1.81, −0.36) | 0.003 | −0.54 (−1.06, −0.02) | 0.041 |
| Duration of time after quitting smoking, years | 0.00 (−0.03, 0.03) | 0.966 | ||
| Current alcohol consumption, yes | −0.10 (−1.46, 1.27) | 0.887 | −0.01 (−1.09, 1.08) | 0.991 |
| BMI, per 1 kg/m2 higher | 0.12 (0.01, 0.23) | 0.031 | 0.02 (−0.08, 0.13) | 0.654 |
| Age (year) per 10 years | −0.93 (−1.48, −0.39) | 0.001 | −0.85 (−1.37, −0.32) | 0.002 |
| Sex: female | 2.68 (1.53, 3.83) | <0.001 | 1.05 (−0.02, 2.12) | 0.055 |
| Race: African American | 3.33 (1.96, 4.70) | <0.001 | 2.42 (1.11, 3.73) | <0.001 |
| Self-reported hypertension | −0.15 (−1.37, 1.06) | 0.807 | ||
| Self-reported diabetes | 1.78 (0.25, 3.31) | 0.022 | 1.12 (−0.28, 2.51) | 0.117 |
| Axial length, per 1mm longer | −0.44 (−0.88, 0.00) | 0.050 | −0.40 (−0.83, 0.03) | 0.071 |
| CCT, per 100 μm thinner | −0.76 (−2.08, 0.56) | 0.261 | ||
| IOP, per 1 mmHg higher | 0.09 (−0.02, 0.20) | 0.108 | −0.06 (−0.16, 0.04) | 0.251 |
| 24–2 VF MD, per 1 dB worse | −0.56 (−0.63, −0.48) | <0.001 | −0.54 (−0.63, −0.46) | <0.001 |
| Average SSI, per 1 higher | 0.17 (0.11, 0.22) | <0.001 | 0.05 (0.00, 0.10) | 0.039 |
BMI = body mass index; CCT = central corneal thickness; IOP = intraocular pressure; MD = mean deviation; SSI = signal strength index; VF = visual field; wiCD = whole image capillary density. Values are shown in mean (95% confidence interval), unless otherwise indicated. Bold text indicates p-value with <0.05.