Table 1.
Histological analysis of pulmonary pathology with IL-4 treatment
| Treatment | Airway damage | Leukocytic interstitial infiltrates | Marginating intravascular segmented neutrophilia (>3 in medium vessels) | Intravascular blasts | Peribronchiolar/peri vascular leukemia infiltration | Leukemia alveolar septal involvement | Leukemia (0 or 1, E=equivocal) |
|---|---|---|---|---|---|---|---|
| Vehicle #1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Vehicle #2 | 0 | 1 | 0 | 1 | 0 | 0 | 1 |
| Vehicle #3 | 0 | 1 | 1 | 1 | 0 | 0 | 1 |
| Vehicle #4 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
| IL-4 #1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
| IL-4 #2 | 0 | 1 | 1 | E | 0 | 0 | E |
| IL-4 #3 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
| IL-4 #4 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
0=absent, 1=present
Lung sections from IL-4 treated mice (n=4) and their counterparts (n=4) were stained with H&E dye. A blinded histological analysis was performed on the sections to score the pulmonary inflammation and leukemia infiltration.