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. 2023 Feb 22;13:1086239. doi: 10.3389/fmicb.2022.1086239

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Copyright © 2023 Li, Zhang, Zhang, Huang, Liu, Lu, Liao, Liu, Zhang and Pan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the structure and composition of bacterial and fungal among HC, CM, and CM treatment groups. (A) Boxplot shows the mean distance of CM, CM_2W, and CM_4w to the HC group on the left. Principal component analysis plot of bacteria based on the Bray–Curtis distance is shown on the right. (B) Boxplot shows the mean distance of CM, CM_2W, and CM_4w to the HC group on the left. Principal component analysis plot of fungal based on the Bray–Curtis distance is shown on the right. HC, healthy control; CM, cryptococcal meningitis; CM-2W, cryptococcal meningitis patients receiving 2 weeks of anti-fungal therapy; CM-4W, cryptococcal meningitis patients receiving 4 weeks of anti-fungal therapy.