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. 2023 Feb 22;13:1086239. doi: 10.3389/fmicb.2022.1086239

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Copyright © 2023 Li, Zhang, Zhang, Huang, Liu, Lu, Liao, Liu, Zhang and Pan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes of the structure and composition of fungal during treatment in CM patients. (A) Alpha diversity analysis plot at the gene level, including the number of genes, and the Shannon index. Dot plots show changes before and after treatment. Dots connected by the gray line represent individuals. (B) Principal component analysis plot based on the Bray–Curtis distance. Individuals are plotted by the same color and connected by the gray line. CM, cryptococcal meningitis; CM-2W, cryptococcal meningitis patients receiving 2 weeks of anti-fungal therapy; CM-4W, cryptococcal meningitis patients receiving 4 weeks of anti-fungal therapy.