Table 2.
MIC, MBC, and MBC/MIC values for melittin, vancomycin, rifampin, gentamicin, and ciprofloxacin against S. aureus and P. aeruginosa.
| Strain | MEL-MIC | MEL-MBC | VAN-MIC | VAN-MBC | RIF-MIC | RIF-MBC | GEN-MIC | GEN-MBC | CIP-MIC | CIP-MBC | VAN-MBC/MIC ratio | RIF-MBC/MIC ratio | GEN-MBC/MIC ratio | CIP-MBC/MIC ratio | MEL-MBC/MIC ratio |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ATCC 29213 | 1.25 | 5 | 1 | 2 | 0.015 | 0.5 | – | – | – | – | 2 | 32 | – | – | 4 |
| MRSA 1 | 2.5 | 5 | 4 | 8 | 0.5 | 8 | – | – | – | – | 2 | 16 | – | – | 2 |
| MRSA 2 | 1.25 | 2.5 | 8 | 16 | 1 | 16 | – | – | – | – | 2 | 16 | – | – | 2 |
| MRSA 3 | 1.25 | 1.25 | 2 | 4 | 1 | 8 | – | – | – | – | 2 | 8 | – | – | 1 |
| MESA 4 | 0.625 | 1.25 | 4 | 8 | 0.5 | 4 | – | – | – | – | 2 | 8 | – | – | 2 |
| MRSA 5 | 2.5 | 5 | 8 | 16 | 2 | 16 | – | – | – | – | 2 | 8 | – | – | 2 |
| MRSA 6 | 1.25 | 2.5 | 4 | 8 | 1 | 8 | – | – | – | – | 2 | 8 | – | – | 2 |
| MRSA 7 | 0.625 | 1.25 | 2 | 4 | 0.25 | 4 | – | – | – | – | 2 | 16 | – | – | 2 |
| MRSA 8 | 2.5 | 5 | 4 | 8 | 0.25 | 8 | – | – | – | – | 2 | 32 | – | – | 2 |
| MRSA 9 | 1.25 | 2.5 | 1 | 2 | 1 | 16 | – | – | – | – | 2 | 16 | – | – | 2 |
| PAO1 | 5 | 10 | – | – | – | – | 0.5 | 8 | 0.25 | 1 | – | – | 16 | 4 | 2 |
| P. aeruginosa 1 | 2.5 | 5 | – | – | – | – | 8 | 128 | 8 | 16 | – | – | 16 | 2 | 2 |
| P. aeruginosa 2 | 5 | 5 | – | – | – | – | 4 | 64 | 2 | 8 | – | – | 16 | 4 | 1 |
| P. aeruginosa 3 | 2.5 | 5 | – | – | – | – | 32 | 256 | 16 | 32 | – | – | 8 | 2 | 2 |
| P. aeruginosa 4 | 10 | 10 | – | – | – | – | 64 | 512 | 32 | 32 | – | – | 8 | 1 | 1 |
| P. aeruginosa 5 | 2.5 | 2.5 | – | – | – | – | 32 | 512 | 1 | 2 | – | – | 8 | 2 | 1 |
| P. aeruginosa 6 | 1.25 | 2.5 | – | – | – | – | 16 | 128 | 2 | 4 | – | – | 8 | 2 | 2 |
| P. aeruginosa 7 | 2.5 | 5 | – | – | – | – | 4 | 64 | 32 | 64 | – | – | 16 | 2 | 2 |
| P. aeruginosa 8 | 5 | 10 | – | – | – | – | 16 | 128 | 16 | 32 | – | – | 16 | 2 | 2 |
| P. aeruginosa 9 | 1.25 | 1.25 | – | – | – | – | 2 | 32 | 64 | 64 | – | – | 16 | 1 | 1 |
Abbreviations: ATCC, American Type Culture Collection; VAN, vancomycin; GEN, gentamicin; CIP, ciprofloxacin; MIC, minimum inhibitory concentration; MBC, minimum bactericidal concentrations; RIF, rifampin, Mel; melittin; MRSA, methicillin-resistant Staphylococcus aureus.