Table 5.
The best synergistic concentrations of gentamicin-melittin and ciprofloxacin-melittin against biofilm of selected P. aeruginosa isolates.
| P. aeruginosa PAO1 | P. aeruginosa 4 | P. aeruginosa 8 | P. aeruginosa PAO1 | P. aeruginosa 7 | P. aeruginosa 8 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| GEN + MEL (μg/ml) | FBIC indices | GEN + MEL (μg/ml) | FBIC indices | GEN + MEL (μg/ml) | FIC indices | CIP + MEL (μg/ml) | FBIC indices | CIP + MEL (μg/ml) | FBIC indices | CIP + MEL (μg/ml) | FBIC indices |
| 4 + 10 | 1.5 | 64 + 5 | 1 | 32 + 2.5 | 0.75 | 2 + 10 | 1.5 | 128 + 10 | 2 | 64 + 10 | 2 |
| 2 + 5 | 0.75 | 32 + 2.5 | 0.5 | 16 + 1.25 | 0.37 | 1 + 5 | 0.75 | 64 + 5 | 1 | 32 + 5 | 1 |
| 1 + 2.5 | 0.37 | 16 + 1.25 | 0.25 | 8 + 0.625 | 0.18 | 0.5 + 2.5 | 0.37 | 32 + 2.5 | 0.5 | 16 + 2.5 | 0.5 |
| 0.5 + 1.25 | 0.18 | 8 + 0.625 | 0.12 | 4 + 0.312 | 0.09 | – | – | 16 + 1.25 | 0.25 | – | – |
| 0.25 + 0.625 | 0.09 | 4 + 0.312 | 0.06 | 2 + 0.156 | 0.04 | – | – | 8 + 0.625 | 0.12 | – | – |
| – | – | 2 + 0.156 | 0.03 | 1 + 0.078 | 0.02 | – | – | – | – | – | – |
| – | – | 1 + 0.078 | 0.01 | 0.5 + 0.039 | 0.01 | – | – | – | – | – | – |
Abbreviation: P. aeruginosa, Pseudomonas aeruginosa; GEN, Gentamicin; MEL, melittin; CIP, Ciprofloxacin; FBIC, fractional biofilm inhibitory concentration.