Table 2.
Comparative Effectiveness of Gastric Bypass and Sleeve Gastrectomy for Percentage of Total Weight Loss (%TWL) and Absolute Difference in Hemoglobin A1c Level Among Adults with Diabetes With 1, 3, and 5 Years of Follow−up, Stratified by Baseline Depression Status
| 1 yr | 3 yr | 5 yr | ||||||
|---|---|---|---|---|---|---|---|---|
| Total Weight Loss, % | N Patients | %TWL | 95% CI | %TWL | 95% CI | %TWL | 95% CI | |
| SG | No Depression | 11522 | −25.2 | (−25.3,−25.0) | −21.3 | (−21.4,−21.1) | −19.2 | (−19.4,−19.0) |
| Depression | 4283 | −24.2 | (−24.5,−24.0) | −20.7 | (−20.9,−20.5) | −19.3 | (−19.6,−19.0) | |
| Difference | 0.97 | (0.7, 1.2) | 0.58 | (0.3, 0.9) | −0.18 | (−0.5, 0.2) | ||
| P-value | <0.001 | <0.001 | 0.300 | |||||
| RYGB | No Depression | 13327 | −30.8 | (−30.9,−30.7) | −28.4 | (−28.6,−28.3) | −25.7 | (−25.8,−25.5) |
| Depression | 6520 | −30.0 | (−30.1,−29.8) | −28.0 | (−28.2,−27.8) | −25.4 | (−25.6,−25.2) | |
| Difference | 0.83 | (0.6, 1.1) | 0.46 | (0.2, 0.7) | 0.23 | (0.0, 0.5) | ||
| P-value | <0.001 | <0.001 | 0.050 | |||||
| Between Group Differences | −0.14 | (−0.47, 0.19) | −0.13 | (−0.47, 0.21) | 0.42 | (0.01, 0.82) | ||
| Interaction P-value | 0.399 | 0.466 | 0.044 | |||||
| 1 yr | 3 yr | 5 yr | ||||||
| Hemoglobin A1c mean difference (95% CI), % | N Patients | Avg. Chg. | 95% CI | Avg. Chg. | 95% CI | Avg. Chg. | 95% CI | |
| SG | No Depression | 1936 | −0.97 | (−1.0,−0.9) | −0.57 | (−0.6,−0.5) | −0.25 | (−0.4,−0.2) |
| Depression | 834 | −0.96 | (−1.0,−0.9) | −0.47 | (−0.6,−0.4) | −0.22 | (−0.4,−0.1) | |
| Difference | 0.01 | (−0.1, 0.1) | 0.10 | (0.0, 0.2) | 0.03 | (−0.1, 0.2) | ||
| P-value | 0.901 | 0.048 | 0.730 | |||||
| RYGB | No Depression | 3612 | −1.12 | (−1.2,−1.1) | −0.76 | (−0.8,−0.7) | −0.54 | (−0.6,−0.5) |
| Depression | 1909 | −1.09 | (−1.1,−1.0) | −0.87 | (−0.9,−0.8) | −0.70 | (−0.8,−0.6) | |
| Difference | 0.03 | (0.0, 0.1) | −0.11 | (−0.2,−0.1) | −0.16 | (−0.2,−0.1) | ||
| P-value | 0.333 | <0.001 | <0.001 | |||||
| Between Group Differences | 0.02 | (−0.08, 0.12) | −0.21 | (−0.32,−0.10) | −0.19 | (−0.37,−0.01) | ||
| Interaction P-value | 0.658 | <0.001 | 0.038 | |||||
Covariates included: age, sex, race, Hispanic ethnicity, baseline BMI, maximum BMI in the prior year, baseline HbA1c, baseline blood pressure, days from most recent BMI measurement to baseline, days from most recent HbA1c measurement to baseline, number of in patient hospital days in the year prior to surgery, Charlson/Elixhauser comorbidity score, year of operation, smoking, and presence of codes for comorbidities (diabetes, hypertension, dyslipidemia, sleep apnea, osteoarthritis, NAFLD, GERD, anxiety, eating disorder, substance use, psychosis, kidney disease, infertility, polycystic ovaries, deep vein thrombosis, pulmonary embolism). RYGB, Roux-en-Y gastric bypass; SG, Sleeve gastrectomy; CI, Confidence interval; Avg Chg, Average Change.