Table 4.
Adjusted Hazard Ratios for Comparison of Time to Different Safety Events for Gastric Bypass and Sleeve Gastrectomy, Stratified by Patients' Baseline Depression Status
| Outcome: Operation or Intervention | ||||||
|---|---|---|---|---|---|---|
| Estimated Cumulative Percentage of Patients With an Operation or Intervention (95% CI) at Different Times of Follow-up | ||||||
| Depression Status | Adjusted HR Comparing RYGB vs SG* (95% CI) | P-value | 1 yr | 3 yr | 5 yr | |
| No Depression | 1.38 (1.22, 1.56) | <0.001 | RYGB | 3.7 (3.4, 4.0) | 8.5 (7.8, 9.1) | 11.9 (11.0, 12.8) |
| SG | 2.7 (2.4, 3.0) | 6.2 (5.6, 6.8) | 8.8 (7.9, 9.6) | |||
| Depression | 1.36 (1.15, 1.60) | <0.001 | RYGB | 3.9 (3.5, 4.3) | 9.0 (8.1, 9.8) | 12.6 (11.4, 13.7) |
| SG | 2.9 (2.5, 3.3) | 6.7 (5.8, 7.6) | 9.4 (8.1, 10.7) | |||
| Interaction P-Value = | 0.856 | |||||
| Outcome: Revision | ||||||
| Estimated Cumulative Percentage of Patients With a Revision (95% CI) at Different Times of Follow-up | ||||||
| Depression Status | Adjusted HR Comparing RYGB vs SG* (95% CI) | P-value | 1 yr | 3 yr | 5 yr | |
| No Depression | 0.79 (0.63, 0.98) | 0.031 | RYGB | 0.9 (0.7, 1.0) | 1.6 (1.4, 1.9) | 2.7 (2.3, 3.1) |
| SG | 1.1 (0.9, 1.3) | 2.1 (1.8, 2.4) | 3.4 (2.9, 4.0) | |||
| Depression | 0.72 (0.54, 0.96) | 0.027 | RYGB | 0.9 (0.7, 1.1) | 1.7 (1.4, 2.0) | 2.8 (2.2, 3.3) |
| SG | 1.3 (1.0, 1.6) | 2.3 (1.8, 2.8) | 3.8 (2.9, 4.7) | |||
| Interaction P-value — | 0.605 | |||||
| Outcome: Endoscopy | ||||||
| Estimated Cumulative Percentage of Patients With an Endoscopy (95% CI) at Different Times of Follow-up | ||||||
| Depression Status | Adjusted HR Comparing RYGB vs SG* (95% CI) | P-value | 1 yr | 3 yr | 5 yr | |
| No Depression | 2.40 (2.12, 2.72) | <0.001 | RYGB | 6.2 (5.8, 6.6) | 10.8 (10.1, 11.5) | 14.8 (13.8, 15.7) |
| SG | 2.6 (2.4, 2.9) | 4.6 (4.2, 5.1) | 6.5 (5.8, 7.1) | |||
| Depression | 1.82 (1.57, 2.11) | <0.001 | RYGB | 7.1 (6.5, 7.6) | 12.2 (11.3, 13.1) | 16.7 (15.4, 17.9) |
| SG | 3.9 (3.4, 4.4) | 6.9 (6.0, 7.8) | 9.5 (8.3, 10.7) | |||
| Interaction P-value = | 0.003 | |||||
Covariates included: site, age, sex, race, Hispanic ethnicity, baseline BMI, HbAlc, and blood pressure categories, days from BMI measurement to bariatric surgery, number of inpatient hospital days in the year before surgery, Charlson/Elixhauser comorbidity category, year of surgery, smoking, and presence of codes for comorbidities (diabetes, hypertension, dyslipidemia, sleep apnea, osteoarthritis, NAFLD, GERD, anxiety, eating disorder, substance use, psychosis, kidney disease, infertility, polycystic ovaries, deep vein thrombosis, pulmonary embolism).
CI, Confidence interval; HR, hazard ratios; RYGB, Roux-en-Y gastric bypass; SG, Sleeve gastrectomy.