Table 2.
Univariable and Multivariable Analyses of Factors Influencing the Risk of Starting Active Treatment
| Active Surveillance (n = 74) | Switch to Active Treatment (n = 31) | Univariable Analysis | Multivariable Analysis | |||
|---|---|---|---|---|---|---|
| n (%) | n (%) | HR [95% CI] | P | HR [95% CI] | P | |
| Age at time of inclusion (median) | 37.0 | 36.0 | 0.99 [0.96–1.02] | 0.481 | ||
| Sex | 0.717 | |||||
| Male | 14 (19%) | 7 (23%) | Ref | |||
| Female | 60 (81%) | 24 (77%) | 0.86 [0.37–1.99] | |||
| Tumor size at baseline (cm) | 0.019 | 0.059 | ||||
| <5 | 48 (65%) | 12 (39%) | Ref | Ref | ||
| ≥5 | 26 (35%) | 19 (61%) | 2.38 [1.15–4.90] | 2.13 [0.97–4.68] | ||
| CTNNB1 mutation status (n = 98)1 | ||||||
| Other 2 | 23 (34%) | 4 (13%) | Ref | Ref | ||
| T41A | 40 (59%) | 17 (57%) | 2.39 [0.80–7.10] | 0.118 | 2.37 [0.80–7.04] | 0.122 |
| S45F | 5 (7%) | 9 (30%) | 6.24 [1.92–20.3] | 0.002 | 4.64 [1.38–15.8] | 0.013 |
1Unknown CTNNB1 mutation status were not included in univariable and multivariable analysis.
2Other: S45P, S33L, H36P, Ser33Tyr, or wild-type (WT) mutations.