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. 2023 Feb 22;11:1110271. doi: 10.3389/fcell.2023.1110271

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Copyright © 2023 Zhang, Liu, Li, Stine, Wang, Turnbull, Wu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptomic analysis of CMs after overexpression of SARS-CoV-2 subunits. (A) The Venn diagram exhibits the statistically differential genes in CMs after overexpression ORF-9B or S (FDR < 0.05) day day32. (B) The heatmap exhibits the expression of overlapping differentially expressed genes in the ORF-9B and S group, compared to that in control. Each group had biological replicates. The representative enriched GO terms (FDR<0.05) are shown on the right side. (C) The scatter plot shows dysregulated genes in the S group compared to that in control (FDR < 0.05 with log[FC] larger than 1). Red, upregulated genes; blue, down-regulated genes. (D, E) The top enriched GO terms (FDR < 0.05) of the downregulated genes (D) and the upregulated genes (E) in the S group. (F) The scatter plot shows dysregulated genes in the ORF-9B group compared to that in control (FDR < 0.05 with log[FC] larger than 1). Red, upregulated genes; blue, down-regulated genes. (G, H) The top enriched GO terms (FDR < 0.05) of the downregulated genes (G) and upregulated genes (H) in the ORF-9B group. (I) The Venn diagram exhibits the statistically differential genes in CMs after overexpression ORF-9B or S (FDR < 0.05) day day45. (J–K) Left, the scatter plot shows dysregulated genes in the S group (J) and ORF-9B group (K) compared to that in control; right, the top enriched GO terms (FDR < 0.05) of the dysregulated genes of each group.