Table 2.
Bivariate analysis of cross-sectional AMH.
| <35 years old (eβ) | P-value | ≥35 years old (odds ratio) | P-value | |
| Age, years | 1.14 (1.02–1.27) | 0.02 | 0.78 (0.71–0.85) | <0.0001 |
| Age2 | 1.00 (0.99–1.00) | 0.004 | ||
| LTL | 1.05 (0.95–1.15) | 0.32 | 1.33 (0.98–1.81) | 0.07 |
| HIV | 0.79 (0.64–0.98) | 0.03 | 0.61 (0.32–1.14) | 0.12 |
| Ethnicity (ref. White) | 0.02 | 0.006 | ||
| Indigenous | 0.70 (0.51–0.95) | 0.34 (0.13–0.89) | ||
| Asian/Southeast Asian | 1.31 (0.93–1.85) | 2.28 (0.89–5.85) | ||
| African/Caribbean/Black | 1.10 (0.82–1.47) | 1.01 (0.40–2.53) | ||
| Other | 0.92 (0.55–1.55) | 2.41 (0.57–10.19) | ||
| BMI, kg/m2 | 1.01 (0.99–1.03) | 0.48 | 0.96 (0.91–1.00) | 0.06 |
| Income (ref. <$15 000 CAD) | 0.01 | 0.0002 | ||
| ≥$15,000 CAD | 1.40 (1.08–1.81) | 3.29 (1.61–6.73) | ||
| N/A | 1.79 (1.13–2.85) | |||
| Education (ref. some high school or less) | 0.09 | 0.02 | ||
| High school graduate or more | 1.23 (0.94–1.61) | 2.41 (1.10–5.26) | ||
| N/A | 1.61 (1.02–2.52) | |||
| Ever infected with HCV | 0.78 (0.57–1.07) | 0.12 | 0.48 (0.25–0.93) | 0.02 |
| Current opioid use | 0.70 (0.53–0.94) | 0.02 | 0.21 (0.08–0.51) | <0.0001 |
| Tobacco smoking (ref. never) | 0.07 | 0.009 | ||
| Current | 0.79 (0.62–1.01) | 0.35 (0.16–0.75) | ||
| Past | 0.70 (0.48–1.02) | 0.77 (0.35–1.67) | ||
| Current psychoactive medication use | 0.93 (0.69–1.25) | 0.63 | 0.83 (0.46–1.51) | 0.54 |
| CD4+ nadir | 1.0005 (0.9999–1.001) | 0.10 | 0.998 (0.996–1.001) | 0.21 |
| Peak HIV VL >100 000 | 0.96 (0.71–1.30) | 0.80 | 0.71 (0.35–1.42) | 0.33 |
| HIV detectable VL | 0.86 (0.69–1.07) | 0.18 | 0.70 (0.31–1.59) | 0.40 |
The relationship between age and AMH levels was nonlinear, as demonstrated by the markedly improved fit between AMH and the quadratic term for age compared to the linear term. As such, the quadratic age term was considered for these models. Age was univariately associated with AMH levels for women under 35 years old and the likelihood of AMH levels ≥2 ng/ml for women aged 35 years or older. For all other potential explanatory variables, bivariate models of AMH are shown, adjusting for age.
AMH, anti-Müllerian hormone; BMI, body mass index; CAD, Canadian dollar; HCV, hepatitis C virus; LTL, leukocyte telomere length; VL, viral load; N/A, not collected, usually because of participant's young age.