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. Author manuscript; available in PMC: 2023 Mar 8.
Published in final edited form as: Nat Genet. 2022 Oct 24;54(11):1609–1614. doi: 10.1038/s41588-022-01200-1

Extended Data Figure 10 |. Fraction of variants found in enriched erythrocytic glycemic gene sets with negative effects on HbA1C levels.

Extended Data Figure 10 |

Reported is the fraction of variants with negative HbA1C effect sizes (based on the single variant meta-analysis) within genes (i) with HbA1C gene-level p≤0.05 and (ii) within a significantly enriched (p≤0.05) erythrocytic (N=4) or glycemic (N=5) gene set. a-g, Results are shown for variants within each mask. The bars represent the fractions observed for variants across all gene sets, while the dots represent the fractions observed for variants within each individual gene set. A two-sided t-test was used to assess potentially significant differences; p-values are shown above each plot. Error bars indicate standard error.