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Frequency of CH mutations among incident lung cancer cases and controls, UKBB. (A) Frequency of overall CH mutations (general additive modeling with spline smoothing) by case-control status and age at blood draw. (B) CH mutations with VAF 2% to < 10%. (C) CH mutations with VAF ≥ 10%. (D) The top 10 most frequent mutated CH genes according to case-control status. CH, clonal hematopoiesis; UKBB, UK Biobank; VAF, variant allele frequency.
