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. 2022 Dec 8;41(7):1423–1433. doi: 10.1200/JCO.22.00857

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© 2022 by American Society of Clinical Oncology

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FIG 2. — CH and risk of incident lung cancer according to (A) lung cancer risk factors and (B) lung cancer characteristics, UKBB. All models were adjusted for age and year at blood draw, sex (female/male), race (White/others), smoking status (never/past/current smoker), pack-years of smoking (continuous), family history of lung cancer (no/yes), and the first 10 principal components of genetic ancestry. Stratified analyses by PRS were additionally adjusted for genotype array (BiLEVE/Axiom) and standardized lung cancer PRS (continuous). Stratified analyses by CRP were additionally adjusted for CRP (continuous). P for interaction was estimated using the Wald test. P for heterogeneity was estimated using polytomous logistic regression. CH, clonal hematopoiesis; CRP, C-reactive protein; OR, odds ratio; PRS, polygenic risk score; UKBB, UK Biobank.