Table 2. Summary of findings for (A) average ADC and D-IVIM, (B) direction-wise MR diffusion and pseudodiffusion among 21 ROI assessed, along with statistical scoring.

Asterisks reflect ‘p’ significance values from the nonparametric Mann-Whitney test comparing diffusion measures between KO vs. WT animals ROI-wise (total n=21, balanced groups), along with the magnitude of the difference expressed by the inequality sign. Legend: OLF-olfactory, CA / RSP-cingulate / retrosplenial, VIS-visual (V1), SS-somatosensory (S1), AUD-auditory, HIP-hippocampus, PERI-perirhinal, TH-thalamus, HAB-habenula, HY-hypothalamus, MB-midbrain, PAG-periaqueductal gray, HB-hindbrain; CP-caudate putamen, WM-white matter; 3V-third ventricle, LV-lateral ventricle, 4V-fourth ventricle, PCS-pericisternal space, CoW-Circle of Willis, CB-cerebellum. NS- no significant difference, *-p<0.05, **-p<0.01, by means of Mann-Whitney U-test.

A	ROI	Average ADC		Average D-IVIM		IVIM
		Finding	Significance	Finding	Significance	D*, Fp, Fp x D*
Cerebral cortex	OLF	KO>WT	*	-	NS	-
	CA / RSP	-	NS	-	NS	-
	VIS	-	NS	-	NS	-
	SS	KO>WT	*	KO>WT	*	-
	AUD	KO>WT	*	KO>WT	*	-
	HIP	KO>WT	**	KO>WT	*	-
	PERI	-	NS	-	NS	-
Brain stem	TH	KO>WT	**	KO>WT	**	-
	HAB	-	NS	-	NS	-
	HY	-	NS	-	NS	-
	MB	KO>WT	*	KO>WT	*	-
	PAG	KO>WT	*	-	NS	-
	HB	KO>WT	**	KO>WT	**	-
Cerebral nuclei and tracts	CP	KO>WT	**	KO>WT	*	-
	WM	KO>WT	*	KO>WT	*	-
CSF space	3V	-	NS	-	NS	-
	LV	-	NS	-	NS	-
	4V	-	NS	-	NS	-
	PCS	-	NS	-	NS	-
	CoW	-	NS	-	NS	-
Cerebellum	CB	-	NS	-	NS	KO>WT Fp = 0.0649
B	ROI	IVIM						ADC / D
		Direction Z(cranio-caudal)		Direction X(bilateral)		Direction Y(ventral-dorsal)		Direction Z (cranio‐caudal)		Direction X (bilateral)		Direction Y (ventral‐dorsal)
		Finding	Signif.	Finding	Signif.	Finding	Signif.	Finding	Signif.	Finding	Signif.	Finding	Signif.
Cerebral cortex	OLF	-	NS	Fp x D* KO>WT	*	-	NS	KO>WT	**/*	-	NS	-	NS
	CA / RSP	D* KO>WT	*	-	NS	-	NS	-	NS	-	NS	-	NS
	VIS	-	NS	-	NS	-	NS	-	NS	KO>WT	*/-	KO>WT	*/-
	SS	-	NS	-	NS	-	NS	KO>WT	-/*	KO>WT	**/ P=0.056	KO>WT	*/-
	AUD	-	NS	-	NS	-	NS	KO>WT	*/*	KO>WT	**/*	KO>WT	*/*
	HIP	-	NS	-	NS	-	NS	KO>WT	*/*	KO>WT	*/-	KO>WT	**/*
	PERI	D* KO>WT	**	-	NS	-	NS	-	NS	KO>WT	*/-	-	NS
Brain stem	TH	-	NS	-	NS	-	NS	KO>WT	**/**	KO>WT	*/-	KO>WT	*/-
	HAB	-	NS	-	NS	-	NS	-	NS	-	NS	-	NS
	HY	-	NS	-	NS	-	NS	-	NS	-	NS	-	NS
	MB	-	NS	-	NS	-	NS	KO>WT	-/*	KO>WT	*/-	KO>WT	**/-
	PAG	-	NS	-	NS	-	NS	KO>WT	*/**	KO>WT	**/-	KO>WT	*/-
	HB	-	NS	-	NS	-	NS	KO>WT	*/*	KO>WT	**/-	KO >WT	*/*
Cerebral nuclei and tracts	CP	-	NS	-	NS	-	NS	KO>WT	**/**	KO>WT	*/-	-	NS
	WM	D* KO>WT	**	-	NS	-	NS	-	NS	-	NS	KO>WT	*/-
CSF space	3V	-	NS	Fp / Fp x D* KO>WT	** / *	-	NS	-	NS	-	NS	-	NS
	LV	-	NS	-	NS	-	NS	-	NS	-	NS	-	NS
	4V	-	NS	-	NS	-	NS	-	NS	-	NS	-	NS
	PCS	-	NS	-	NS	-	NS	-	NS	-	NS	-	NS
	CoW	-	NS	-	NS	-	NS	-	NS	-	NS	-	NS
Cerebellum	CB	-	NS	-	NS	-	NS	-	NS	-	NS	-	NS