Skip to main content
. Author manuscript; available in PMC: 2023 Jul 10.
Published in final edited form as: Sci Signal. 2023 Jan 10;16(767):eabm5518. doi: 10.1126/scisignal.abm5518

Table 1.

Inhibitory potency of peptide sequences identified by PSSMsearch.

Protein Sequence JNK1
search
rank		 JNK1
PSSM		 p38α
search
rank		 p38α
PSSM		 JNK1 IC50,
μM (95% CI)		 p38α IC50, μM
(95% CI)
AFAP1L2 KQVRKKEHKLKITP - - 4 Other >100 40 (34 - 47)
RASGRF1 SPSRRRKLSLNIPI 74 NFAT 2 MEF2A 1.1 (0.89 - 1.3) 2.4 (2.0 - 2.9)
WDR3 KRKRKKREKLILTL 25 NFAT 7 Other 0.90 (0.81 - 1.0) 0.30 (0.24 - 0.36)
TTLL13P RRRKRRSLAINLTN 10 NFAT 48 MEF2A 1.8 (1.7 - 2.0) 0.76 (0.64 - 0.90)
MXD4 EKHRRAKLRLYLEQ 1 NFAT 34 MEF2A 1.1 (0.95 - 1.3) 5.2 (3.5 - 7.8)
MYH14 GEQRRRRLELQLQE 8 NFAT - - 5.6 (4.6 - 6.9) 35 (26 - 49)
CDX1 YPGPARPASLGLGP 36 JIP - - 2.7 (2.4 - 3.0) >100