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The semi-open state as a functional rescue for downstream signaling. (a) N-WASP has the preponderance to stay closed and hence is unable to bind Arp2/3. (b) In the semi-open state, the freed A tail can engage with Arp2/3. This pre-engagement primes Arp2/3 to pull the A motif away from the BR, thereby creating a bypass to full binding. (c) N-WASP rarely samples the open state on its own.
