Table 2. Summary of included case series.

N = number of MPXV-positive patients, NR = not reported; PCR = polymerase chain reaction; MPXV = monkeypox virus

Author, Year	N	Mean Age	Gender, % male	Pain prevalence	Pain Initial Symptom?	Pain region	Pain Intensity	Method of diagnosis	Treatment
Pfafflin, 2022 [25]	6	NR	100%	Anal pain (n=6)	No	Anorectal	5/10 10/10 9/10 10/10 10/10 10/10	PCR	Metamizole 500 mg q6h Lidocaine 50 mg/g topical Stool softeners Ibuprofen
Patel, 2022 [15]	197	38	100%	Rectal pain (n=71) Sore throat (n=33) Penile oedema (n=31)	Yes	Right thigh Right sided neck pain Penis Ano-rectal	Severe. No score reported	PCR	Fentanyl Acetaminophen Ibuprofen Opioids Lidocaine gel Rectal suppositories Oral laxatives
Moschese, 2022 [26]	34	NR	100%	Patients hospitalized due to pain (n=1)	Yes	Not reported	Severe. No score reported	PCR	Analgesic therapy. Not specified
Thornhil, 2022 [4]	528	38	98%	Headache (n=145) Myalgia (n=165) Proctitis (n=75)	Not specified	Anorectal (21/528)	Severe. No score reported	PCR	No reported