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Combinatory therapeutics strategy derived using drug-gene network
Drug-gene network analysis for ENZ-induced (A) and ENZ-resistant gene signatures (B). ENZ-driven gene signatures are shown in the middle of each network, connected by dotted line. Predicted candidate drugs with potential combinatory use are shown if they target genes driven by the ENZ treatment. Predicted drugs are colored according to their connectivity score, with orange being negative and blue positive.
