Table 1.
DeSigN prediction of drug candidates for enzalutamide-responsive phenotype
| Drug | Gene target | Connectivity score | p value |
|---|---|---|---|
| Shikonin | undefined | 1.000 | 0.000 |
| Lapatinib | EGFR, ERBB2 | 0.992 | 0.018 |
| Bleomycin | LIG1, LIG3 | 0.991 | 0.028 |
| A-443654 | undefined | 0.991 | 0.029 |
| CGP-082996 | undefined | 0.990 | 0.015 |
| Erlotinib | EGFR, NR1I2 | 0.989 | 0.021 |
| WZ-1-84 | undefined | 0.989 | 0.018 |
| CGP-60474 | undefined | 0.983 | 0.039 |
| SL-0101-1 | undefined | 0.980 | 0.046 |
| A-770041 | Undefined | 0.980 | 0.032 |
| BX-795 | CDK2, CHEK1, GSK3B, KDR, PDK1, PDPK1 | −1.000 | 0.000 |