Table 2.
DeSigN predictions of drug candidates for ENZ-resistant phenotype
| Drug | Target | Connectivity score | p value |
|---|---|---|---|
| AKT-inhibitor-VIII | undefined | 1.000 | 0.000 |
| Etoposide | TOP2A, TOP2B | 0.994 | 0.008 |
| OSU-03012 | undefined | 0.989 | 0.021 |
| Bleomycin | LIG1, LIG3 | 0.987 | 0.020 |
| PD-0332991 | CDK4, CDK6 | 0.977 | 0.031 |
| QS11 | undefined | 0.973 | 0.046 |
| AZD6482 | PIK3CA, PIK3CB, PIK3CD, PIK3CG | 0.972 | 0.040 |
| GW843682X | undefined | −0.969 | 0.043 |
| BX-795 | CDK2, CHEK1, GSK3B, KDR, PDK1, PDPK1 | −0.973 | 0.049 |
| GNF-2 | ABL1, BCR | −0.976 | 0.042 |
| Nilotinib | ABL1, KIT | −0.977 | 0.047 |
| AZ628 | undefined | −0.980 | 0.036 |
| WO2009093972 | undefined | −0.982 | 0.029 |
| Roscovitine | CDK2, CDK9 | −0.989 | 0.018 |
| AS601245 | undefined | −0.990 | 0.014 |
| Nutlin-3a | undefined | −1.000 | 0.000 |