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. 2023 Feb 23;10:1056064. doi: 10.3389/fmed.2023.1056064

Table 4.

Incidences of adverse pregnancy outcomes and neonatal outcomes for the mixture group with different ages and parities.

Variables Total (%) Nulliparas Multiparas p
A1 (%) A2 (%) A3 (%) AMA (%) vAMA (%) A1 (%) A2 (%) A3 (%) AMA (%) vAMA (%)
n 15,861 2,541 7,821 1,374 230 36 45 236 2,262 1,084 232
Gestational hypertension 740 (4.67) 66 (2.60) 308 (3.94) 77 (5.60) 30 (13.04) 6 (16.67) 2 (4.44) 9 (3.81) 100 (4.42) 106 (9.78) 36 (15.52) 0.00***
Eclampsia/pre-eclampsia 537 (3.39) 30 (1.18) 223 (2.85) 72 (5.24) 20 (8.70) 4 (11.11) 1 (2.22) 7 (2.97) 74 (3.27) 77 (7.10) 29 (12.50) 0.00***
Gestational diabetes mellitus 3,633 (22.91) 474 (18.65) 1,689 (21.60) 362 (26.35) 88 (38.26) 14 (38.89) 7 (15.56) 47 (19.92) 521 (23.03) 348 (32.10) 83 (35.78) 0.00***
Intrahepatic cholestasis of pregnancy 374 (2.36) 58 (2.28) 196 (2.51) 35 (2.55) 5 (2.17) 2 (5.56) 1 (2.22) 5 (2.12) 42 (1.86) 24 (2.21) 6 (2.59) 0.80
Anemia 262 (1.65) 35 (1.38) 112 (1.43) 22 (1.60) 5 (2.17) 2 (5.56) 1 (2.22) 6 (2.54) 52 (2.30) 22 (2.03) 5 (2.16) 0.07
Placenta previa 279 (1.76) 20 (0.79) 77 (0.98) 23 (1.67) 10 (4.35) 3 (8.33) 0 4 (1.69) 57 (2.52) 67 (6.18) 18 (7.76) 0.00***
Placental abruption 174 (1.10) 26 (1.02) 80 (1.02) 14 (1.02) 3 (1.30) 1 (2.78) 1 (2.22) 3 (1.27) 29 (1.28) 14 (1.29) 3 (1.29) 0.95
Placental implantation 170 (1.07) 28 (1.10) 70 (0.90) 12 (0.87) 3 (1.30) 1 (2.78) 0 1 (0.42) 21 (0.93) 26 (2.40) 8 (3.45) 0.00***
Premature rupture of membrane 2,845 (17.94) 473 (18.61) 1,454 (18.59) 253 (18.41) 42 (18.26) 6 (16.67) 7 (15.56) 38 (16.10) 365 (16.14) 169 (15.59) 38 (16.38) 0.14
Postpartum hemorrhage 665 (4.19) 80 (3.15) 296 (3.78) 60 (4.37) 12 (5.22) 4 (11.11) 2 (4.44) 8 (3.39) 104 (4.60) 77 (7.10) 22 (9.48) 0.00***
Oligohydramnios 741 (4.67) 114 (4.49) 360 (4.60) 62 (4.51) 11 (4.78) 2 (5.56) 2 (4.44) 11 (4.66) 106 (4.69) 53 (4.89) 20 (8.62) 0.79
Preterm birth 1,870 (11.79) 286 (11.26) 874 (11.18) 137 (9.97) 37 (16.09) 6 (16.67) 7 (15.56) 33 (13.98) 276 (12.20) 174 (16.05) 40 (17.24) 0.00***
Cesarean section 8,878 (55.97) 1,102 (43.37) 3,980 (50.89) 749 (54.51) 194 (84.35) 31 (86.11) 21 (46.67) 153 (64.83) 1,589 (70.25) 869 (80.17) 190 (81.90) 0.00***
Macrosomia 549 (3.46) 88 (3.46) 250 (3.20) 48 (3.49) 7 (3.04) 0 2 (4.44) 8 (3.39) 89 (3.93) 48 (4.43) 9 (3.88) 0.55
Fetal distress 206 (1.30) 32 (1.26) 99 (1.270) 18 (1.31) 3 (1.30) 1 (2.78) 1 (2.22) 3 (1.27) 30 (1.33) 15 (1.38) 4 (1.72) 0.1
Transfer to neonatal unit 2,296 (14.48) 305 (12.00) 1,095 (14.00) 227 (16.52) 48 (20.87) 13 (36.11) 4 (8.89) 25 (10.59) 313 (13.84) 208 (19.19) 58 (25.00) 0.00***
Neonatal jaundice 778 (4.91) 117 (4.60) 382 (4.88) 62 (4.51) 11 (4.78) 1 (2.78) 2 (4.44) 12 (5.08) 109 (4.82) 62 (5.72) 20 (8.62) 0.37
Apgar score <7 within 5 min of birth 278 (1.75) 32 (1.26) 123 (1.57) 22 (1.60) 4 (1.74) 1 (2.78) 1 (2.22) 4 (1.69) 50 (2.21) 32 (2.95) 9 (3.88) 0.01*

*p < 0.05, statistically difference, **p < 0.01, statistically significant difference, ***p < 0.001, highly statistically significant difference. A1: 20–24 years old women, A2: 25–29 years old women, A3: 30–34 years old women, AMA: 35–39 years old women, and vAMA: ≥ 40 years old women.