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. 2023 Feb 23;14:1135952. doi: 10.3389/fphar.2023.1135952

FIGURE 5.

FIGURE 5

Withaferin A inhibits diet-induced fibrosis and fibrogenic signaling. (A) Representative liver sections stained with Masson’s trichome stain (MTS) with a scale bar of 50 μM. (B) Secretion of TGF-β1 by the liver in the withaferin A-treated WDSW-induced NAFLD mouse model measured by ELISA. (C) Relative mRNA expression of TGF-β1 target genes: COL1A1, COL3A1, and α-SMA were analyzed using qPCR.