Table 1.
Demographics and Baseline Clinical Characteristics of the Subjects
| POAG eyes (n=144 eyes of 100 patients) | |||
|---|---|---|---|
| Early glaucoma | Moderate-advanced glaucoma | P value | |
| Characteristic | n= 80 eyes of 62 patients | n= 64 eyes of 53 patients | |
| Age (years) | 78.7 (76.7, 80.6) | 79.8 (77.8, 81.7) | 0.213 |
| Gender (Female/ Male) | 34/28 | 25/28 | 0.697 |
| Race (African American/ non-African American) | 12/50 | 8/45 | 0.635 |
| Hypertension (Hypertensive/ non-hypertensive) | 38/24 | 36/17 | 0.303 |
| Diabetes (Diabetic/ non-diabetic) | 7/55 | 9/44 | 0.412 |
| IOP (mmHg) | 14.6 (13.5, 15.6) | 13.2 (11.6, 14.5) | 0.089 |
| VF MD (dB) | −2.7 (−3.1, −2.3) | −13.4 (−14.5, −11.5) | <0.001 |
| VF PSD (dB) | 4.0 (3.5, 4.5) | 9.7 (9.0, 10.4) | <0.001 |
| LogMAR VA | 0.05 (0.03, 0.07) | 0.11 (0.08, 0.13) | 0.003 |
| Decreased VA (%) | 9 (11%) | 24 (38%) | <0.001 |
| Corrected FAZ area (mm2) | 0.30 (0.27, 0.33) | 0.30 (0.27, 0.33) | 0.979 |
| FAZ circumference (mm) | 2.06 (1.94, 2.17) | 2.10 (1.99, 2.21) | 0.661 |
| FD300 (%) | 49.2 (47.8, 50.5) | 45.8 (44.2, 47.4) | 0.003 |
| fGCC (μm) | 53.0 (50.4, 55.6) | 49.0 (45.6, 52.4) | 0.055 |
| pfGCC (μm) | 87.5 (84.6, 90.5) | 79.1 (75.2, 83.0) | 0.001 |
| perifGCC (μm) | 79.9 (77.7, 82.0) | 74.1 (71.4, 76.7) | 0.001 |
| wiGCC (μm) | 81.0 (78.9, 83.1) | 74.7 (72.1, 77.3) | <0.001 |
| Superficial fVD (%) | 17.6 (16.0, 19.1) | 18.0 (16.0, 19.9) | 0.803 |
| Superficial pfVD (%) | 43.8 (42.6, 45.0) | 40.5 (39.2, 41.8) | 0.002 |
| Superficial perifVD (%) | 40.2 (39.3, 41.1) | 36.0 (34.9, 37.1) | <0.001 |
| Superficial wiVD (%) | 40.1 (39.3, 41.0) | 36.2 (35.1, 37.3) | <0.001 |
| Deep fVD (%) | 32.7 (30.8, 34.5) | 31.6 (29.7, 33.5) | 0.489 |
| Deep pfVD (%) | 50.0 (49.0, 51.1) | 47.4 (46.2, 48.5) | 0.003 |
| Deep perifVD (%) | 44.5 (43.3, 45.8) | 41.3 (39.8, 42.7) | 0.003 |
| Deep wiVD (%) | 44.1 (42.9, 45.2) | 41.1 (39.8, 42.4) | 0.003 |
| OCT/OCTA SSI | 59.0 (57.5, 60.5) | 57.4 (55.9, 58.9) | 0.192 |
*
Values are shown in mean (95% confidence interval), unless otherwise indicated.
Abbreviations: f = foveal; FAZ = foveal avascular zone; FD300 = foveal density 300; GCC = ganglion cell complex; IOP = intraocular pressure; MD = mean deviation; OCT = optical coherence tomography; OCTA = optical coherence tomography angiography; No. = number; PSD = pattern standard deviation; perif = perifoveal; pf = parafoveal; SSI = signal strength index; VA = visual acuity; VD = vessel density; VF = visual field; wi = whole-image