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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: J Physiol. 2022 Sep 27;601(11):2139–2163. doi: 10.1113/JP283261

Figure 11. Decreased histidine intake prevents diet-induced obesity and glucose intolerance, and is associated with lower BMI in humans.

Figure 11.

(A) Experimental scheme. (B-E) Body weight (B), fat mass and lean mass (C), dermal WAT thickness (D), and body composition (E) of mice consuming the indicated diets. (B, C, E) n=6–12 mice per group, *p<0.05 vs. all other groups, Tukey’s test following a mixed-effects model (Restricted Maximum Likelihood (REML). (D) n=6–7/group, *p<0.05 vs. WD Ctrl AA, Dunnett’s test post ANOVA. (F) Food consumption (n=6 cages per group, *p<0.05, Sidak’s test post 2-way RM ANOVA). (G) Energy expenditure (heat) normalized to body weight of mice fed the indicated diets (n=5–6 mice per group, *p<0.05, Sidak’s test post 2-way RM ANOVA). (H) Glucose tolerance test after 3 weeks on the indicated diets (n=12/group, *p<0.05 vs. WD Ctrl AA, Dunnett’s test post ANOVA). (I) Association between BMI and percent of total protein from histidine from the SHOW study (n = 788, shaded area represents 95% CI). Data represented as mean ± SEM.