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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: J Physiol. 2022 Sep 27;601(11):2139–2163. doi: 10.1113/JP283261

Figure 7. Restricting dietary histidine improves glycemic control and hepatic steatosis of DIO mice.

Figure 7.

(A) Glucose tolerance test after 3 weeks on the indicated diets (n=10–12/group, *p<0.05 vs. WD Ctrl AA, Dunnett’s test post ANOVA). (B) Insulin tolerance test after 4 weeks on the indicated diets (n=9–12/group, *p<0.05 vs. WD Ctrl AA, Dunnett’s test post ANOVA). (C-E) Representative Oil-Red-O-stained sections of liver of mice after 9 weeks on the indicated diets. Scale bar, 100 µm (C); quantification of lipid droplet area (D) and lipid droplet size (E) (n=6/group, *p<0.05 vs. WD Ctrl AA, Dunnett’s test post ANOVA). (F) Lipogenic gene expression after 9 weeks on the indicated diets (n=6/group, *p<0.05 vs. WD Ctrl AA, Dunnett’s test post 2-way RM ANOVA). Data represented as mean ± SEM.