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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: J Physiol. 2022 Sep 27;601(11):2139–2163. doi: 10.1113/JP283261

Figure 8. Dietary restriction of histidine increases glucose uptake into multiple tissues of DIO mice.

Figure 8.

(A-C) Glucose infusion rate (A), basal and clamp hepatic glucose production (B), insulin responsiveness (C) and glucose disposal rate (D) were determined during a hyperinsulinemic-euglycemic clamp in mice preconditioned with a WD for 12 weeks and then switched to a WD Ctrl AA diet or a WD Low His diet for 4 weeks (n = 5/group; (A,C) *p<0.05, t-test; (B, D) *p < 0.05, Sidak’s test post 2-way ANOVA). (E-J) Glucose uptake into iWAT (E), BAT (F), heart (G), muscle (H), eWAT (I), and brain (J) were determined during a hyperinsulinemic-euglycemic clamp in mice preconditioned with a WD for 12 weeks and then switched to a WD Ctrl AA diet or a WD Low His diet for 4 weeks (n = 5/group; *p<0.05, t-test). (K-L) Core temperature was determined using a rectal thermometer at room temp (24°C) (K) and after 1 hour at 4°C (L); n = 3/group, *p < 0.05, t-test. WD Ctrl AA clamp and glucose uptake data has been previously published (Yu et al., 2021). Data represented as mean ± SEM.