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. 2023 Feb 23;15:1028178. doi: 10.3389/fnagi.2023.1028178

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Copyright © 2023 Xu, Li, Li, Li, Lv, Zhang, Shi and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of NBP on neurological deficit scores, brain water content, and cerebral infarct area. (A) Neurological deficit score. (B) Brain water content. (C) TTC staining. (D) Infarct volume. (E) Cerebral Blood Flow Measurement (From left to right, normal, ischemia and reperfusion). MCAO, middle cerebral artery occlusion; NBP, N-butylphthalide; TTC, 2,3,5-Triphenyltetrazolium chloride; MCAO/R + NBP-L, Low-dose N-butylphthalide, 10 mg/kg; MCAO/R + NBP-M, Medium-dose N-butylphthalide, 20 mg/kg; MCAO/R + NBP-H, High-dose N-butylphthalide, 30 mg/kg. *p < 0.05; **p < 0.01; ***p < 0.001. The values represent the mean ± SD, n = 6.